Tesamorelin

Tesamorelin — Stabilized GHRH Analog Research Peptide

Tesamorelin is a synthetic GHRH analog originally developed by Theratechnologies and approved by the FDA in 2010 as Egrifta for the reduction of excess visceral adipose tissue in HIV-associated lipodystrophy. It is structurally a GHRH (1-44) molecule with a trans-3-hexenoyl (N-terminal) modification that protects against DPP-4 cleavage and gives it a substantially longer functional half-life than unmodified Sermorelin. In the peptide-research toolkit, Tesamorelin is the most-studied GHRH analog with a published clinical outcome dataset on visceral fat and IGF-1 endpoints.

Why Tesamorelin’s Stabilization Matters

Native GHRH (and Sermorelin) are degraded by DPP-4 within minutes, producing a short pulse of GH release. Tesamorelin’s trans-3-hexenoyl group blocks DPP-4 cleavage, which means a larger fraction of the dose reaches the pituitary GHRH receptor and the GH pulse it triggers is longer and larger. That stabilization is what produced the visceral-fat endpoints in the published HIV-lipodystrophy trials – results that shorter-acting GHRH analogs (like Sermorelin) do not have in clinical-trial form.

Tesamorelin vs Sermorelin vs CJC-1295 No DAC

All three are GHRH analogs that hit the same receptor; they differ in how long they stay active and in how much published outcome data exists for each.

Forschungsanwendungen

Tesamorelin is used in studies examining:

• Visceral adipose tissue (VAT) and body-composition endpoints
• IGF-1 elevation and dose-response under a stabilized GHRH analog
• Hepatic steatosis and liver-fat endpoints (documented in published HIV-lipodystrophy follow-on work)
• Paired GHRH + GHRP study designs (commonly with Ipamorelin)
• Comparative pharmacokinetics vs. Sermorelin and CJC-1295 No DAC
• Long-duration GH/IGF-1 axis characterization

Technische Daten

Rekonstitution

Tesamorelin arrives as a freeze-dried powder and is reconstituted with bacteriostatic water:

Gesamtmenge in mg im Fläschchen ÷ hinzugefügte Wassermenge in ml = mg pro ml

Beispiel: Eine 5-mg-Ampulle + 2 ml bakteriostatisches Wasser = 2,5 mg pro ml. Eine 10-mg-Ampulle + 2 ml = 5 mg pro ml.

Nach der Zubereitung bei 2–8 °C lagern und innerhalb von 28–30 Tagen verbrauchen.

Anmerkungen zum Protokoll

The following values are reference points extracted from published Tesamorelin clinical research – not instructions. The Egrifta Phase 3 program used a standardized daily dose, and most published research protocols mirror that.

• Dose reported in the literature: 2mg per administration is the Egrifta label dose and the most commonly cited research value
• Administration frequency in published studies: Once daily, typically pre-sleep to align with nocturnal GH release
• Study durations reported: 26-52 weeks in published Phase 3 and extension trials for visceral-fat and IGF-1 endpoints

Common Questions About Tesamorelin Research

What does Tesamorelin do in research?

It activates the pituitary GHRH receptor and triggers a sustained pulse of GH release. Downstream, GH converts to IGF-1 in the liver, which is the primary biomarker tracked in most studies. Because Tesamorelin resists DPP-4 cleavage, the published literature includes visceral-fat and body-composition endpoints that shorter-acting GHRH analogs do not.

How does Tesamorelin compare to Sermorelin?

They are both GHRH analogs that hit the same pituitary receptor, but Tesamorelin is stabilized and Sermorelin is not. Sermorelin is the unmodified GHRH (1-29) fragment, degraded by DPP-4 within minutes. Tesamorelin is GHRH (1-44) with a trans-3-hexenoyl N-terminal modification that blocks DPP-4 cleavage and produces a longer, larger GH pulse.

How does Tesamorelin compare to Ipamorelin?

They act through different receptors. Tesamorelin is a GHRH analog (initiates the GH pulse via the GHRH receptor). Ipamorelin is a GHRP (amplifies the pulse via the ghrelin receptor). They are not interchangeable – researchers often pair them because the two pathways work together.

Is Tesamorelin FDA approved?

Yes. Tesamorelin is FDA-approved as Egrifta for the reduction of excess visceral adipose tissue in HIV-associated lipodystrophy. It is not approved for any other indication. Every vial WWP ships is labeled and sold strictly for laboratory and research use only.

How is Tesamorelin stored?

Ungeöffnete Fläschchen werden bei 2–8 °C gelagert und sind mindestens 12 Monate haltbar. Nach der Rekonstitution mit bakteriostatischem Wasser wird die Lösung bei 2–8 °C aufbewahrt und innerhalb von 28–30 Tagen verbraucht.

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