Tesamorelin

Tesamorelin - Stabilized GHRH Analog Research Peptide

Tesamorelin is a synthetic GHRH analog originally developed by Theratechnologies and approved by the FDA in 2010 as Egrifta for the reduction of excess visceral adipose tissue in HIV-associated lipodystrophy. It is structurally a GHRH (1-44) molecule with a trans-3-hexenoyl (N-terminal) modification that protects against DPP-4 cleavage and gives it a substantially longer functional half-life than unmodified Sermorelin. In the peptide-research toolkit, Tesamorelin is the most-studied GHRH analog with a published clinical outcome dataset on visceral fat and IGF-1 endpoints.

Why Tesamorelin’s Stabilization Matters

Native GHRH (and Sermorelin) are degraded by DPP-4 within minutes, producing a short pulse of GH release. Tesamorelin’s trans-3-hexenoyl group blocks DPP-4 cleavage, which means a larger fraction of the dose reaches the pituitary GHRH receptor and the GH pulse it triggers is longer and larger. That stabilization is what produced the visceral-fat endpoints in the published HIV-lipodystrophy trials - results that shorter-acting GHRH analogs (like Sermorelin) do not have in clinical-trial form.

Tesamorelin vs Sermorelin vs CJC-1295 No DAC

All three are GHRH analogs that hit the same receptor; they differ in how long they stay active and in how much published outcome data exists for each.

Aplicaciones de investigación

Tesamorelin is used in studies examining:

• Visceral adipose tissue (VAT) and body-composition endpoints
• IGF-1 elevation and dose-response under a stabilized GHRH analog
• Hepatic steatosis and liver-fat endpoints (documented in published HIV-lipodystrophy follow-on work)
• Paired GHRH + GHRP study designs (commonly with Ipamorelin)
• Comparative pharmacokinetics vs. Sermorelin and CJC-1295 No DAC
• Long-duration GH/IGF-1 axis characterization

Especificaciones

Storage & Handling

Unopened vials are kept at 2-8°C under standard cold-chain conditions and remain stable for 12+ months. Reconstitution parameters, solvent compatibility, and post-reconstitution stability for Tesamorelin are documented in the published peer-reviewed literature and standard peptide-chemistry references.

Reference Literature

Published clinical and preclinical Tesamorelin literature is available through PubMed, Google Scholar, and other peer-reviewed databases. WWP does not provide protocol design, dosing guidance, or administration parameters. Those decisions rest with the researcher and any applicable institutional review board.

Common Questions About Tesamorelin Research

What does Tesamorelin do in research?

It activates the pituitary GHRH receptor and triggers a sustained pulse of GH release. Downstream, GH converts to IGF-1 in the liver, which is the primary biomarker tracked in most studies. Because Tesamorelin resists DPP-4 cleavage, the published literature includes visceral-fat and body-composition endpoints that shorter-acting GHRH analogs do not.

How does Tesamorelin compare to Sermorelin?

They are both GHRH analogs that hit the same pituitary receptor, but Tesamorelin is stabilized and Sermorelin is not. Sermorelin is the unmodified GHRH (1-29) fragment, degraded by DPP-4 within minutes. Tesamorelin is GHRH (1-44) with a trans-3-hexenoyl N-terminal modification that blocks DPP-4 cleavage and produces a longer, larger GH pulse.

How does Tesamorelin compare to Ipamorelin?

They act through different receptors. Tesamorelin is a GHRH analog (initiates the GH pulse via the GHRH receptor). Ipamorelin is a GHRP (amplifies the pulse via the ghrelin receptor). They are not interchangeable - researchers often pair them because the two pathways work together.

Is Tesamorelin FDA approved?

Yes. Tesamorelin is FDA-approved as Egrifta for the reduction of excess visceral adipose tissue in HIV-associated lipodystrophy. It is not approved for any other indication. Every vial WWP ships is labeled and sold strictly for laboratory and research use only.

How is Tesamorelin stored?

Los viales sin abrir se conservan a una temperatura de entre 2 y 8 °C y se mantienen estables durante más de 12 meses. Una vez reconstituida con agua bacteriostática, la solución se conserva a una temperatura de entre 2 y 8 °C y debe utilizarse en un plazo de 28 a 30 días.

Garantía de pureza

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