SLU-PP-332
$475.00
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Mengenrabatte
Preis pro Packung (10 Ampullen). Der Rabatt gilt nur für dieses Präparat – keine Kombination mit anderen Produkten.
| Anzahl | Preis | Ersparnisse |
|---|---|---|
| 1 Packung | $475 | - |
| 2 Packungen | $404 | 15 % Rabatt |
| 3 Packungen | $343 | 28 % Rabatt |
| 5 Packungen | $309 | 35 % Rabatt |
| 10 Packungen | $278 | 41 % Rabatt |
| 25 Packungen | $250 | 47 % Rabatt |
SLU-PP-332 — Pan-ERR Agonist Exercise-Mimetic Research Compound
SLU-PP-332 is a synthetic pan-agonist of the three estrogen-related receptors (ERRα, ERRβ, ERRγ) – orphan nuclear receptors that sit at the center of the transcriptional program exercise activates in skeletal muscle. It was developed at Saint Louis University (the “SLU” in the name) and described in a 2023 publication as a tool compound for probing ERR signaling in vivo. SLU-PP-332 is the reference small-molecule ERR pan-agonist in the current research toolkit – it is not a peptide, and its research utility comes from its ability to transcriptionally upregulate mitochondrial biogenesis and oxidative metabolism without physical training.
Why the Pan-ERR Mechanism Matters
The ERR family (α, β, γ) regulates the transcriptional program that drives mitochondrial biogenesis, oxidative-phosphorylation gene expression, and fatty-acid oxidation capacity. This is the same program exercise training activates. SLU-PP-332’s pan-ERR agonism turns on this program at the transcriptional level, which is why it shows up in published work as an “exercise-mimetic” research compound. It sits at a different point in the mitochondrial-axis toolkit than SS-31 (structural protection) or MOTS-c (AMPK signaling) – it is transcriptional and works upstream of mitochondrial content changes.
| Studiengang | Was es im Klartext bedeutet |
|---|---|
| ERRα / ERRβ / ERRγ | Pan-agonized – full orphan nuclear receptor family transcriptional activation |
| Mitochondrial biogenesis | Upregulated – PGC-1α axis drives new mitochondrial content |
| Oxidative phosphorylation | Gene expression increased – greater oxidative capacity |
| Fatty-acid oxidation | Upregulated – shift toward fat utilization |
| Exercise-mimetic endpoints | Increased running-endurance time in published rodent studies (no training) |
SLU-PP-332 vs Other Mitochondrial-Axis Compounds
The mitochondrial-axis research toolkit has a small group of compounds. They act at different points in the pathway.
| Verbundstoff | Mitochondrialer Mechanismus |
|---|---|
| SLU-PP-332 | Pan-ERR agonist – transcriptionally drives mitochondrial biogenesis |
| MOTS-c | Mitochondrial-encoded peptide – AMPK activation and metabolic signaling |
| SS-31 (Elamipretid) | Cardiolipin binder – structurally stabilizes existing respiratory chain |
Forschungsanwendungen
SLU-PP-332 is used in studies examining:
- Pan-ERR agonism and transcriptional mitochondrial biogenesis endpoints
- Exercise-mimetic and running-endurance research (without training)
- Fatty-acid oxidation and substrate utilization models
- Obesity and diet-induced metabolic syndrome research
- Comparative mitochondrial-axis research (SLU-PP-332 vs MOTS-c vs SS-31)
- ERR pharmacology and orphan nuclear receptor biology
Technische Daten
| Format | Gefriergetrocknetes Pulver |
| Reinheit | ≥99% |
| Molekularklasse | Kleinmolekül (kein Peptid) |
| Aliasnamen | SLU-PP-332, SLU PP 332, pan-ERR agonist |
| Lagerung | 2–8 °C ungeöffnet; mindestens 12 Monate haltbar |
| Verwendung | Nur für Forschungszwecke – nicht zur Anwendung am Menschen |
Rekonstitution
SLU-PP-332 arrives as a freeze-dried powder. Reconstitute with bacteriostatic water:
Gesamtmenge in mg im Fläschchen ÷ hinzugefügte Wassermenge in ml = mg pro ml
Nach der Zubereitung bei 2–8 °C lagern und innerhalb von 28–30 Tagen verbrauchen.
Anmerkungen zum Protokoll
The following values are reference points extracted from published SLU-PP-332 research – not instructions. The published in vivo rodent work used daily subcutaneous administration over multi-week windows.
- Dose range reported in the rodent literature: ~50mg/kg per administration in the original mouse studies
- Administration frequency in published studies: Daily subcutaneous
- Study durations reported: 4-12 weeks for metabolic and endurance endpoint studies
Common Questions About SLU-PP-332 Research
What is SLU-PP-332 used for in research?
It is studied as the reference pan-ERR agonist research compound. Published work covers transcriptional mitochondrial biogenesis, exercise-mimetic endurance endpoints in untrained animals, fatty-acid oxidation, obesity and metabolic syndrome models, and ERR pharmacology.
Is SLU-PP-332 a peptide?
No. SLU-PP-332 is a small-molecule ligand, not a peptide. It binds directly to the ligand-binding domains of the three ERR nuclear receptors. It appears in the research-compound toolkit alongside peptides because its mitochondrial / exercise-mimetic research axis overlaps heavily with MOTS-c and other peptide-adjacent metabolic compounds.
How does SLU-PP-332 compare to MOTS-c?
Both are studied for mitochondrial endpoints but work at different points in the pathway. SLU-PP-332 acts transcriptionally through pan-ERR agonism – it turns on the gene expression program that builds new mitochondria. MOTS-c acts post-transcriptionally through AMPK activation – it modulates how existing mitochondria operate. Both are “exercise-mimetic” but through distinct mechanisms.
Is SLU-PP-332 FDA approved?
No. SLU-PP-332 is a research tool compound published in 2023 for probing ERR biology in vivo. It is not in clinical trials and has no approved-drug status. Every vial WWP ships is labeled and sold strictly for laboratory and research use only.
How is SLU-PP-332 stored?
Unopened vials are stored at 2-8°C and stay stable for 12+ months. Once reconstituted, store at 2-8°C and use within 28-30 days.
Reinheitsgarantie
Jede Charge weist eine Reinheit von ≥99 % auf. Senden Sie uns ein Analysezertifikat einer unabhängigen Prüfstelle, und wir stellen Ihnen unabhängig vom Ergebnis eine Gutschrift aus.
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