SLU-PP-332
Fat Loss & Body Composition

SLU-PP-332

$218.00

Per vial
$21.80
10 vials per pack
Suggested retail
$65.40
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SLU-PP-332 - Pan-ERR Agonist Exercise-Mimetic Research Compound

SLU-PP-332 is a synthetic pan-agonist of the three estrogen-related receptors (ERRα, ERRβ, ERRγ) - orphan nuclear receptors that sit at the center of the transcriptional program exercise activates in skeletal muscle. It was developed at Saint Louis University (the “SLU” in the name) and described in a 2023 publication as a tool compound for probing ERR signaling in vivo. SLU-PP-332 is the reference small-molecule ERR pan-agonist in the current research toolkit - it is not a peptide, and its research utility comes from its ability to transcriptionally upregulate mitochondrial biogenesis and oxidative metabolism without physical training.

Why the Pan-ERR Mechanism Matters

The ERR family (α, β, γ) regulates the transcriptional program that drives mitochondrial biogenesis, oxidative-phosphorylation gene expression, and fatty-acid oxidation capacity. This is the same program exercise training activates. SLU-PP-332’s pan-ERR agonism turns on this program at the transcriptional level, which is why it shows up in published work as an “exercise-mimetic” research compound. It sits at a different point in the mitochondrial-axis toolkit than SS-31 (structural protection) or MOTS-c (AMPK signaling) - it is transcriptional and works upstream of mitochondrial content changes.

Pathway What it does in plain terms
ERRα / ERRβ / ERRγ Pan-agonized - full orphan nuclear receptor family transcriptional activation
Mitochondrial biogenesis Upregulated - PGC-1α axis drives new mitochondrial content
Oxidative phosphorylation Gene expression increased - greater oxidative capacity
Fatty-acid oxidation Upregulated - shift toward fat utilization
Exercise-mimetic endpoints Increased running-endurance time in published rodent studies (no training)

SLU-PP-332 vs Other Mitochondrial-Axis Compounds

The mitochondrial-axis research toolkit has a small group of compounds. They act at different points in the pathway.

Compound Mitochondrial mechanism
SLU-PP-332 Pan-ERR agonist - transcriptionally drives mitochondrial biogenesis
MOTS-c Mitochondrial-encoded peptide - AMPK activation and metabolic signaling
SS-31 (elamipretide) Cardiolipin binder - structurally stabilizes existing respiratory chain

Research Applications

SLU-PP-332 is used in studies examining:

  • Pan-ERR agonism and transcriptional mitochondrial biogenesis endpoints
  • Exercise-mimetic and running-endurance research (without training)
  • Fatty-acid oxidation and substrate utilization models
  • Obesity and diet-induced metabolic syndrome research
  • Comparative mitochondrial-axis research (SLU-PP-332 vs MOTS-c vs SS-31)
  • ERR pharmacology and orphan nuclear receptor biology

Specifications
Format Lyophilized powder
Purity ≥99%
Molecular class Small molecule (not a peptide)
Aliases SLU-PP-332, SLU PP 332, pan-ERR agonist
Storage 2-8°C unopened; stable 12+ months
Use Research purposes only - not for human use

Storage & Handling

Unopened vials are kept at 2-8°C under standard cold-chain conditions and remain stable for 12+ months. Reconstitution parameters, solvent compatibility, and post-reconstitution stability for SLU-PP-332 are documented in the published peer-reviewed literature and standard peptide-chemistry references.

Reference Literature

Published clinical and preclinical SLU-PP-332 literature is available through PubMed, Google Scholar, and other peer-reviewed databases. WWP does not provide protocol design, dosing guidance, or administration parameters. Those decisions rest with the researcher and any applicable institutional review board.

Common Questions About SLU-PP-332 Research

What is SLU-PP-332 used for in research?

It is studied as the reference pan-ERR agonist research compound. Published work covers transcriptional mitochondrial biogenesis, exercise-mimetic endurance endpoints in untrained animals, fatty-acid oxidation, obesity and metabolic syndrome models, and ERR pharmacology.

Is SLU-PP-332 a peptide?

No. SLU-PP-332 is a small-molecule ligand, not a peptide. It binds directly to the ligand-binding domains of the three ERR nuclear receptors. It appears in the research-compound toolkit alongside peptides because its mitochondrial / exercise-mimetic research axis overlaps heavily with MOTS-c and other peptide-adjacent metabolic compounds.

How does SLU-PP-332 compare to MOTS-c?

Both are studied for mitochondrial endpoints but work at different points in the pathway. SLU-PP-332 acts transcriptionally through pan-ERR agonism - it turns on the gene expression program that builds new mitochondria. MOTS-c acts post-transcriptionally through AMPK activation - it modulates how existing mitochondria operate. Both are “exercise-mimetic” but through distinct mechanisms.

Is SLU-PP-332 FDA approved?

No. SLU-PP-332 is a research tool compound published in 2023 for probing ERR biology in vivo. It is not in clinical trials and has no approved-drug status. Every vial WWP ships is labeled and sold strictly for laboratory and research use only.

How is SLU-PP-332 stored?

Unopened vials are stored at 2-8°C and stay stable for 12+ months. Once reconstituted, store at 2-8°C and use within 28-30 days.

Purity Guarantee

Every batch is ≥99% purity. Send us a COA from any independent test and we’ll issue store credit regardless of what it shows.

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