Selank

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Precio por envase (10 viales). El descuento se aplica únicamente a este compuesto; no se admiten combinaciones.

Selank — Tuftsin-Derived Anxiolytic Heptapeptide with Immunomodulatory Activity

Selank is a synthetic heptapeptide developed at the Institute of Molecular Genetics of the Russian Academy of Sciences alongside Semax, designed as a stable analogue of the endogenous immunomodulatory tetrapeptide tuftsin (Thr-Lys-Pro-Arg). The parent molecule, tuftsin, is a fragment of the IgG heavy chain that stimulates phagocyte activity and innate immune function. Selank extends tuftsin with a C-terminal Gly-Glu-Pro sequence, which dramatically increases metabolic stability — the native tuftsin half-life is minutes; Selank’s is measured in hours — and shifts the pharmacological profile toward CNS activity. Selank was registered as a pharmaceutical in Russia for the treatment of generalized anxiety disorder and neurasthenia and is listed in the Russian State Pharmacopoeia. It does not bind GABA-A receptors directly but modulates GABAergic tone through downstream regulatory mechanisms, producing anxiolytic activity in preclinical models without the sedation, tolerance, or withdrawal profile associated with benzodiazepines.

Why Selank’s Mechanism Differs from Classical Anxiolytics

Most anxiolytics act as direct GABA-A receptor positive allosteric modulators (benzodiazepines) or serotonin reuptake inhibitors. Selank’s anxiolytic activity does not involve direct receptor binding at either site. Instead, it modulates endogenous enkephalin expression — increasing met-enkephalin levels — and upregulates BDNF in hippocampal and prefrontal regions. It also regulates cytokine signaling: in animal models, Selank normalizes elevated IL-6 and TNF-α under stress conditions, suggesting a neuro-immune axis component to its activity. The compound’s ability to produce anxiolytic effects without altering motor coordination or inducing dependence in rodent models distinguishes it from all classical anxiolytic drug classes.

Aplicaciones de investigación

Selank is used in studies examining:

• Anxiety and stress response models — elevated plus maze, open field, forced swim; GABAergic vs. non-GABAergic anxiolytic mechanisms
• Neuro-immune axis — cytokine regulation under psychological stress, IL-6/TNF-α normalization
• BDNF and enkephalin expression — neuropeptide regulation by tuftsin analogues
• Cognitive function under stress — attention, working memory, and executive function in anxiety models
• Dependence liability profiling — comparison to benzodiazepines in chronic administration paradigms
• Immunomodulation — macrophage activation, phagocyte function (tuftsin-lineage effects)

Especificaciones

Reconstitución

Selank arrives as lyophilized powder and must be reconstituted with bacteriostatic water prior to use. Use the formula:

Total en mg ÷ Volumen añadido (mL) = Concentración (mg/mL)

Ejemplo: vial de 5 mg + 1 ml de agua BAC = solución de 5 mg/ml; vial de 10 mg + 2 ml de agua BAC = solución de 5 mg/ml

El péptido reconstituido debe conservarse a una temperatura de entre 2 y 8 °C y utilizarse en un plazo de 28 a 30 días.

Notas sobre el protocolo

La bibliografía sobre ensayos clínicos y la investigación preclínica rusas ofrecen los siguientes marcos de referencia, no instrucciones de uso:

• Dose range: 250–500mcg intranasal per session in Russian clinical literature; 25–100mcg/kg SC in rodent studies
• Frequency: 1–3 times daily in clinical trials; once daily in most chronic rodent model studies
• Study duration: 2-week cycles documented in registered clinical studies; 4–8 weeks in chronic anxiety model research

Pilas de investigación

Selank is commonly paired in research settings with:

• Semax — Semax upregulates BDNF and activates melanocortin receptors to support neuroplasticity, while Selank modulates enkephalin degradation and GABAergic tone. Researchers pair both to study complementary neuroprotective and anxiolytic signaling within the same in vitro or in vivo model.
• DSIP — DSIP (Delta Sleep-Inducing Peptide) acts on sleep-regulatory circuits; pairing with Selank, which reduces anxiety-related neuronal activity, is used in studies examining the intersection of stress modulation and sleep architecture.
• Cerebrolysin — Cerebrolysin delivers neurotrophic peptide fragments that support neuronal survival and synaptic density. Combined with Selank’s anxiolytic and enkephalinase-inhibiting properties, the pairing is studied in models of cognitive resilience and stress-related neurodegeneration.

Garantía de pureza

Cada lote tiene una pureza ≥99 %. Si sometes tu compuesto a un análisis independiente y los resultados no coinciden, envíanos el certificado de análisis (COA) y te concederemos un vale de compra sin hacerte preguntas.