Selank

Selank — Tuftsin-Analog GABAergic Anxiolytic Research Peptide

Selank is a synthetic heptapeptide analog of the immune-regulatory peptide tuftsin, developed at the Russian Academy of Medical Sciences in the late 1990s as a nootropic / anxiolytic research compound alongside Semax. Structurally it is tuftsin (Thr-Lys-Pro-Arg) extended with a Pro-Gly-Pro C-terminal stabilizer, which gives Selank a plasma half-life long enough for CNS research that native tuftsin lacks. In research, Selank is the reference GABAergic-signaling research peptide – its anxiolytic endpoint profile overlaps with classical benzodiazepine research but through distinct mechanisms (enkephalin upregulation and modulation of GABAergic signaling rather than direct GABA-A binding).

Why the Tuftsin-Analog Structure Matters

Tuftsin (Thr-Lys-Pro-Arg) is a naturally occurring immune-system peptide that is rapidly cleaved in plasma. Selank’s C-terminal Pro-Gly-Pro extension is a stabilizer used across several Russian research peptides (Semax uses the same Pro-Gly-Pro tail). That extension gives Selank a circulating half-life of ~20+ minutes – long enough to cross the blood-brain barrier and reach CNS targets. Selank’s research distinction is that it engages the GABAergic / enkephalin axis rather than the melanocortin-derived ACTH fragments that anchor Semax.

Selank vs Semax

The two compounds are compared constantly in Russian nootropic-research literature. They share a Pro-Gly-Pro stabilizer tail but target completely different neurochemical axes.

Forschungsanwendungen

Selank is used in studies examining:

• GABAergic and enkephalin-pathway anxiolytic endpoints
• Stress-response and anxiety models (generalized anxiety, neurasthenia)
• Serotonin turnover and mood-regulation research
• Comparative nootropic-peptide research (Selank vs Semax)
• Immune-modulation research (tuftsin-derived anti-viral endpoints)
• Non-benzodiazepine anxiolytic mechanism studies

Technische Daten

Rekonstitution

Selank arrives as a freeze-dried powder and is reconstituted with bacteriostatic water:

Gesamtmenge in mg im Fläschchen ÷ hinzugefügte Wassermenge in ml = mg pro ml

Beispiel: Eine 5-mg-Ampulle + 2 ml bakteriostatisches Wasser = 2,5 mg pro ml. Eine 10-mg-Ampulle + 2 ml = 5 mg pro ml.

Nach der Zubereitung bei 2–8 °C lagern und innerhalb von 28–30 Tagen verbrauchen.

Anmerkungen zum Protokoll

The following values are reference points extracted from published Selank research – not instructions. Russian clinical trial work has used both subcutaneous injection and intranasal routes.

• Dose range reported in the literature: 250-900mcg per administration
• Administration frequency in published studies: Once to three times daily
• Study durations reported: 2-6 weeks for anxiolytic and stress-response endpoint studies

Common Questions About Selank Research

What is Selank used for in research?

It is studied as the reference tuftsin-analog anxiolytic research peptide. Published work covers GABAergic / enkephalin-pathway anxiolytic endpoints, stress-response and anxiety models, serotonin turnover, immune-modulation research, and comparative nootropic-peptide research against Semax.

What is the difference between Selank and Semax?

Both are Russian-developed nootropic research peptides with the same Pro-Gly-Pro stabilizer tail, but they target different neurochemical systems. Selank is a tuftsin analog that engages the GABAergic / enkephalin anxiolytic axis. Semax is an ACTH(4-10) melanocortin fragment analog that engages the BDNF / dopaminergic cognitive-enhancement axis. Selank is anxiety-focused; Semax is cognition-focused.

What is N-Acetyl Selank Amidate?

N-Acetyl Selank Amidate is a modified variant of Selank with an acetyl group on the N-terminus and an amide cap on the C-terminus. Those modifications extend plasma half-life by increasing resistance to aminopeptidase and carboxypeptidase cleavage. In research, it shows up when longer duration of action is required than unmodified Selank provides.

Is Selank FDA approved?

No. Selank is not an FDA-approved drug product. It is approved as a prescription anxiolytic in Russia but has no regulatory status in the United States or European Union. Every vial WWP ships is labeled and sold strictly for laboratory and research use only.

How is Selank stored?

Ungeöffnete Fläschchen werden bei 2–8 °C gelagert und sind mindestens 12 Monate haltbar. Nach der Rekonstitution mit bakteriostatischem Wasser wird die Lösung bei 2–8 °C aufbewahrt und innerhalb von 28–30 Tagen verbraucht.

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