Epithalon

Epithalon – Ala-Glu-Asp-Gly Tetrapeptide Research Compound

Epithalon (also spelled Epitalon) is a synthetic tetrapeptide with the sequence Ala-Glu-Asp-Gly, developed by Vladimir Khavinson and the St. Petersburg Institute of Bioregulation and Gerontology beginning in the 1980s. It is the short-chain synthetic mimetic of Epithalamin, a pineal-gland extract used in the original Russian longevity research. Epithalon is the most-studied “short bioregulator” in the published literature – a single, well-defined sequence whose research axis sits on telomerase activation, pineal function, and circadian signaling.

Why Telomerase Activation Matters

Telomeres are the repeating DNA caps at the ends of chromosomes that shorten with each cell division. Telomerase is the enzyme that rebuilds them. Khavinson’s group published in-vitro work showing Epithalon upregulates telomerase activity and extends the replicative lifespan of cultured cells. That finding is what places Epithalon in the longevity-research category rather than a nootropic or metabolic category – the downstream endpoints being measured are fundamentally about replicative aging.

Epithalon vs Epitalon vs Epithalamin

The three names are frequently confused. They describe related but distinct compounds.

Epithalon is the synthetic short-chain sequence that Khavinson’s group identified as the active component of the Epithalamin extract. “Epitalon” and “Epithalon” are alternate transliterations of the Russian name – there is no chemical difference between the two.

Forschungsanwendungen

Epithalon is used in studies examining:

• Telomerase (hTERT) activation and telomere-length endpoints
• Replicative cell-lifespan in-vitro
• Pineal function and endogenous melatonin rhythm
• Circadian-gene expression models
• Longevity and age-related gene-expression endpoints
• Comparative bioregulator research (vs Pinealon, Thymalin)

Technische Daten

Rekonstitution

Epithalon arrives as a freeze-dried powder and is reconstituted with bacteriostatic water:

Gesamtmenge in mg im Fläschchen ÷ hinzugefügte Wassermenge in ml = mg pro ml

Example: a 10mg vial + 2mL of bacteriostatic water = 5mg per mL. A 50mg vial + 2mL = 25mg per mL.

Nach der Zubereitung bei 2–8 °C lagern und innerhalb von 28–30 Tagen verbrauchen.

Anmerkungen zum Protokoll

The following values are reference points extracted from published Epithalon research – not instructions. Khavinson’s published protocols use a short intensive course rather than continuous dosing, which is the dominant pattern in the research literature.

• In der Literatur angegebener Dosierungsbereich: 5–10 mg pro Verabreichung
• Administration frequency in published studies: Once daily for a 10-20 day course, followed by a long off-window before the next course
• Study durations reported: 10-20 day intensive courses; annual or semi-annual repetition in Khavinson’s longer-term published series

Common Questions About Epithalon Research

What is Epithalon used for in research?

Epithalon is studied primarily on the longevity axis. Published work covers telomerase (hTERT) activation, telomere-length maintenance, pineal function and melatonin rhythm, circadian signaling, and age-related gene expression. It is the most-cited compound in the “short bioregulator” research category.

What is the difference between Epitalon and Epithalon?

There is no chemical difference. Both names describe the synthetic Ala-Glu-Asp-Gly tetrapeptide. “Epitalon” is closer to the Russian transliteration; “Epithalon” is the Anglicized spelling. Research papers use both interchangeably.

Is Epithalon the same as Epithalamin?

No. Epithalamin is the original pineal-gland extract (a mixture of peptides). Epithalon is the synthetic tetrapeptide that Khavinson’s group identified as the active short-chain component. They are not interchangeable – Epithalon has a defined single sequence; Epithalamin does not.

Is Epithalon FDA approved?

No. Epithalon is not FDA approved in the United States. It was studied and used clinically in Russia but has never been submitted for US regulatory review. Every vial WWP ships is labeled and sold strictly for laboratory and research use only.

How is Epithalon stored?

Ungeöffnete Fläschchen werden bei 2–8 °C gelagert und sind mindestens 12 Monate haltbar. Nach der Rekonstitution mit bakteriostatischem Wasser wird die Lösung bei 2–8 °C aufbewahrt und innerhalb von 28–30 Tagen verbraucht.

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