5-Amino-1MQ
Anti-Aging & Longevity

5-Amino-1MQ

$89.00

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10 vials per pack
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5-Amino-1MQ - Selective NNMT Inhibitor Research Compound

5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule selective inhibitor of NNMT (nicotinamide N-methyltransferase), first published by Neelakantan and colleagues in 2017. Unlike most compounds WWP stocks, 5-Amino-1MQ is not a peptide - it is a membrane-permeable small molecule that blocks a specific methylation enzyme. Its research profile is built around adipose-tissue metabolism, NAD+ pool regulation, and methyl-donor flux. It is most often compared to NAD+ and NAD+ precursors because both affect the same pyridine-nucleotide pool, just from opposite directions.

Why NNMT Inhibition Matters

NNMT methylates nicotinamide (NAM) to form 1-methylnicotinamide (MNA), using S-adenosylmethionine (SAM) as the methyl donor. The reaction sinks both NAM and SAM - two metabolically central substrates. In adipose tissue, elevated NNMT activity correlates with obesity and insulin resistance. Blocking NNMT with 5-Amino-1MQ preserves the NAM pool (feeds back into NAD+ salvage) and spares SAM (improves methylation flux elsewhere). That is the mechanistic rationale behind the published adipose-tissue and body-composition research on the compound.

Pathway What it does in plain terms
NNMT enzyme Inhibited - nicotinamide no longer methylated and excreted
NAD+ salvage pathway Preserved NAM feeds back into NAD+ recycling
SAM / methyl-donor pool Spared - not consumed by the NNMT reaction
Adipocyte energy expenditure Increased lipolysis reported in published in-vitro and rodent work

5-Amino-1MQ vs NAD+ / NR / NMN

All four compounds influence the NAD+ pool, but they act at different points in the pathway.

Compound Mechanism
5-Amino-1MQ Inhibits NNMT - blocks NAM excretion, preserves NAD+ precursor pool
NAD+ (direct) Supplies the cofactor directly - bypasses salvage pathway
NR (nicotinamide riboside) Precursor - enters the salvage pathway one step upstream of NAD+
NMN (nicotinamide mononucleotide) Precursor - enters the salvage pathway two steps upstream of NAD+

5-Amino-1MQ is unique among them because it does not supply any precursor - it blocks the enzyme that drains the pool.

Research Applications

5-Amino-1MQ is used in studies examining:

  • NNMT activity and selective enzyme inhibition
  • NAD+ / NAM pool regulation and salvage-pathway flux
  • Adipose-tissue metabolism and lipolysis endpoints
  • SAM / methyl-donor pool research
  • Insulin-sensitivity and body-composition models
  • Comparative research vs. NAD+, NR, and NMN

Specifications
Format Lyophilized powder
Purity ≥99%
Aliases 5-Amino-1-methylquinolinium iodide, 5A1MQ, NNMT inhibitor
Molecular class Small molecule (not a peptide)
Storage 2-8°C unopened; stable 12+ months
Use Research purposes only - not for human use

Storage & Handling

Unopened vials are kept at 2-8°C under standard cold-chain conditions and remain stable for 12+ months. Reconstitution parameters, solvent compatibility, and post-reconstitution stability for 5-Amino-1MQ are documented in the published peer-reviewed literature and standard peptide-chemistry references.

Reference Literature

Published clinical and preclinical 5-Amino-1MQ literature is available through PubMed, Google Scholar, and other peer-reviewed databases. WWP does not provide protocol design, dosing guidance, or administration parameters. Those decisions rest with the researcher and any applicable institutional review board.

Common Questions About 5-Amino-1MQ Research

What does 5-Amino-1MQ do in research?

It selectively inhibits NNMT, the enzyme that methylates nicotinamide into 1-methylnicotinamide. Blocking NNMT preserves the NAM pool (feeds back into NAD+ salvage) and spares the SAM methyl-donor pool. Downstream, published work tracks adipose-tissue lipolysis, insulin sensitivity, and body-composition endpoints.

What is the difference between 5-Amino-1MQ and NAD+?

They influence the same NAD+ pool from opposite directions. NAD+ supplies the cofactor directly; 5-Amino-1MQ inhibits the enzyme that drains the precursor pool. NR and NMN are precursors that feed the salvage pathway. Combination research exists because the mechanisms are complementary rather than redundant.

Is 5-Amino-1MQ a peptide?

No. 5-Amino-1MQ is a small-molecule quinolinium derivative, not a peptide. It is the only non-peptide research compound in most “peptide” research catalogs, and it is included because its NAD+/NNMT research axis overlaps heavily with peptide-adjacent longevity and body-composition literature.

Is 5-Amino-1MQ FDA approved?

No. 5-Amino-1MQ is not FDA approved for any use. It is a research compound only. Every vial WWP ships is labeled and sold strictly for laboratory and research use only.

How is 5-Amino-1MQ stored?

Unopened vials are stored at 2-8°C and stay stable for 12+ months. Once reconstituted with bacteriostatic water, the solution is kept at 2-8°C and used within 28-30 days.

Purity Guarantee

Every batch is ≥99% purity. Send us a COA from any independent test and we’ll issue store credit regardless of what it shows.

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