5-ammino-1MQ

5-Amino-1MQ — Selective NNMT Inhibitor Research Compound

5-Amino-1MQ (5-amino-1-methylquinolinium) is a small-molecule selective inhibitor of NNMT (nicotinamide N-methyltransferase), first published by Neelakantan and colleagues in 2017. Unlike most compounds WWP stocks, 5-Amino-1MQ is not a peptide – it is a membrane-permeable small molecule that blocks a specific methylation enzyme. Its research profile is built around adipose-tissue metabolism, NAD+ pool regulation, and methyl-donor flux. It is most often compared to NAD+ and NAD+ precursors because both affect the same pyridine-nucleotide pool, just from opposite directions.

Why NNMT Inhibition Matters

NNMT methylates nicotinamide (NAM) to form 1-methylnicotinamide (MNA), using S-adenosylmethionine (SAM) as the methyl donor. The reaction sinks both NAM and SAM – two metabolically central substrates. In adipose tissue, elevated NNMT activity correlates with obesity and insulin resistance. Blocking NNMT with 5-Amino-1MQ preserves the NAM pool (feeds back into NAD+ salvage) and spares SAM (improves methylation flux elsewhere). That is the mechanistic rationale behind the published adipose-tissue and body-composition research on the compound.

5-Amino-1MQ vs NAD+ / NR / NMN

All four compounds influence the NAD+ pool, but they act at different points in the pathway.

5-Amino-1MQ is unique among them because it does not supply any precursor – it blocks the enzyme that drains the pool.

Applicazioni di ricerca

5-Amino-1MQ is used in studies examining:

• NNMT activity and selective enzyme inhibition
• NAD+ / NAM pool regulation and salvage-pathway flux
• Adipose-tissue metabolism and lipolysis endpoints
• SAM / methyl-donor pool research
• Insulin-sensitivity and body-composition models
• Comparative research vs. NAD+, NR, and NMN

Specifiche tecniche

Ricostituzione

5-Amino-1MQ arrives as a freeze-dried powder and is reconstituted with bacteriostatic water:

Totale in mg nella fiala ÷ ml di acqua aggiunta = mg per ml

Una volta ricostituito, conservare a una temperatura compresa tra 2 e 8 °C e utilizzare entro 28-30 giorni.

Note sul protocollo

The following values are reference points extracted from published 5-Amino-1MQ research – not instructions. Because 5-Amino-1MQ is membrane-permeable, both oral and subcutaneous routes appear in the published literature.

• Dose range reported in the literature: 50-150mg per administration in rodent models scaled to equivalent human-range research protocols
• Administration frequency in published studies: Once daily is the most commonly documented pattern
• Study durations reported: 4-12 weeks for adipose-tissue and body-composition endpoints

Common Questions About 5-Amino-1MQ Research

What does 5-Amino-1MQ do in research?

It selectively inhibits NNMT, the enzyme that methylates nicotinamide into 1-methylnicotinamide. Blocking NNMT preserves the NAM pool (feeds back into NAD+ salvage) and spares the SAM methyl-donor pool. Downstream, published work tracks adipose-tissue lipolysis, insulin sensitivity, and body-composition endpoints.

What is the difference between 5-Amino-1MQ and NAD+?

They influence the same NAD+ pool from opposite directions. NAD+ supplies the cofactor directly; 5-Amino-1MQ inhibits the enzyme that drains the precursor pool. NR and NMN are precursors that feed the salvage pathway. Combination research exists because the mechanisms are complementary rather than redundant.

Is 5-Amino-1MQ a peptide?

No. 5-Amino-1MQ is a small-molecule quinolinium derivative, not a peptide. It is the only non-peptide research compound in most “peptide” research catalogs, and it is included because its NAD+/NNMT research axis overlaps heavily with peptide-adjacent longevity and body-composition literature.

Is 5-Amino-1MQ FDA approved?

No. 5-Amino-1MQ is not FDA approved for any use. It is a research compound only. Every vial WWP ships is labeled and sold strictly for laboratory and research use only.

How is 5-Amino-1MQ stored?

Le fiale non aperte vanno conservate a una temperatura compresa tra 2 e 8 °C e mantengono la loro stabilità per oltre 12 mesi. Una volta ricostituita con acqua batteriostatica, la soluzione va conservata a una temperatura compresa tra 2 e 8 °C e utilizzata entro 28-30 giorni.

Garanzia di purezza

Ogni lotto ha una purezza pari o superiore al 99%. Inviateci un certificato di analisi (COA) redatto da un ente indipendente e vi accrediteremo un buono acquisto indipendentemente dai risultati riportati.