IGF-1 LR3

IGF-1 LR3 — Long Arg3 IGF-1 Analog Research Peptide

IGF-1 LR3 (Long R3 Insulin-like Growth Factor-1) is a synthetic 83-amino-acid analog of native IGF-1 with two modifications: a 13-amino-acid N-terminal extension (the “Long” segment) and an arginine substitution at position 3 that replaces the native glutamate. Both modifications reduce binding to IGF binding proteins (IGFBPs), which extends the peptide’s circulating half-life from roughly 10-20 minutes (native IGF-1) to around 20-30 hours. IGF-1 LR3 is the reference research analog for studying sustained IGF-1 receptor (IGF-1R) activation without the rapid IGFBP sequestration that limits native IGF-1 in vivo.

Why the IGFBP-Resistant Profile Matters

In circulation, roughly 99% of native IGF-1 is bound to IGFBPs (primarily IGFBP-3) and only a small free fraction is bioactive. The Arg3 substitution in IGF-1 LR3 drops IGFBP affinity substantially, and the N-terminal extension further blocks binding-protein association. The result is a peptide that stays free and bioactive for an extended window – which is the specific property research protocols are after when they need sustained IGF-1R signaling rather than a short pulse.

IGF-1 LR3 vs IGF-1 DES vs Native IGF-1

The three IGF-1 research variants are compared regularly in hypertrophy and regeneration literature. Each modifies a different structural feature of the native sequence.

Applicazioni di ricerca

IGF-1 LR3 is used in studies examining:

• IGF-1 receptor agonism and PI3K/Akt signaling endpoints
• Satellite-cell activation and skeletal-muscle hypertrophy research
• Extended IGF-1R activation (vs native IGF-1’s short pulse)
• Comparative research vs IGF-1 DES and native IGF-1
• Paired research with GH-axis compounds (sermorelin, tesamorelin, CJC-1295)
• Cellular glucose uptake and IGF-1R / insulin-receptor cross-talk

Specifiche tecniche

Ricostituzione

IGF-1 LR3 arrives as a freeze-dried powder and is reconstituted with bacteriostatic water:

Totale in mg nella fiala ÷ ml di acqua aggiunta = mg per ml

Example: a 1mg vial + 1mL of bacteriostatic water = 1mg per mL (1,000mcg per mL). A 0.1mg (100mcg) vial + 1mL = 100mcg per mL.

Una volta ricostituito, conservare a una temperatura compresa tra 2 e 8 °C e utilizzare entro 28-30 giorni.

Note sul protocollo

The following values are reference points extracted from published IGF-1 LR3 research – not instructions. Because of the extended half-life, once-daily dosing is the dominant pattern in the published literature.

• Dose range reported in the literature: 20-80mcg per administration
• Administration frequency in published studies: Once daily
• Study durations reported: 4-6 week intensive courses are the dominant pattern

Common Questions About IGF-1 LR3 Research

What is IGF-1 LR3 used for in research?

It is studied as the long-acting IGF-1R agonist. Published work covers PI3K/Akt and MAPK signaling, satellite-cell activation, skeletal-muscle hypertrophy endpoints, cellular glucose uptake research, and comparative work against IGF-1 DES and native IGF-1.

What is the difference between IGF-1 LR3 and native IGF-1?

IGF-1 LR3 carries two modifications – a 13-amino-acid N-terminal extension and an arginine substitution at position 3 – that dramatically reduce IGF binding protein (IGFBP) affinity. The result is an extended plasma half-life (20-30 hours vs 10-20 minutes for native IGF-1) and sustained IGF-1 receptor activation in circulation.

How does IGF-1 LR3 compare to IGF-1 DES?

IGF-1 LR3 has an extended half-life and produces systemic IGF-1R signaling. IGF-1 DES (1-3) has the N-terminal tripeptide removed, which gives it ultra-short half-life and localized signaling. Research designs choose between them based on whether the study question requires sustained exposure or a highly localized pulse.

Is IGF-1 LR3 FDA approved?

No. IGF-1 LR3 is not FDA approved for any use. Recombinant native IGF-1 (mecasermin) is FDA approved for severe primary IGF-1 deficiency, but the LR3 analog is not. It is also prohibited under the WADA Prohibited List. Every vial WWP ships is labeled and sold strictly for laboratory and research use only.

How is IGF-1 LR3 stored?

Le fiale non aperte vanno conservate a una temperatura compresa tra 2 e 8 °C e mantengono la loro stabilità per oltre 12 mesi. Una volta ricostituita con acqua batteriostatica, la soluzione va conservata a una temperatura compresa tra 2 e 8 °C e utilizzata entro 28-30 giorni.

Garanzia di purezza

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