GHRP-2

GHRP-2 - Pralmorelin Ghrelin-Receptor Agonist Research Peptide

GHRP-2 (also known as pralmorelin, KP-102) is a synthetic hexapeptide first developed by Bowers and colleagues in the 1990s as a second-generation growth hormone-releasing peptide. It binds the GHSR-1a receptor (the ghrelin receptor) in the anterior pituitary and hypothalamus, triggering pulsatile growth hormone (GH) release without disturbing the native somatostatin feedback loop. GHRP-2 is the most-studied compound in the “ghrelin mimetic” research category and is used as the reference secretagogue alongside GHRP-6, ipamorelin, and hexarelin.

Why the GHSR-1a Binding Profile Matters

GHRP-2’s research distinction is its GH-release potency relative to its appetite-signaling effect. Most ghrelin-receptor agonists couple GH release with measurable increases in hunger-axis signaling (NPY, AgRP). GHRP-2 is positioned between GHRP-6 (strong appetite effect) and ipamorelin (minimal appetite effect) - its research utility is in protocols that want reliable GH pulsatility without the pronounced hunger-axis signal GHRP-6 produces.

GHRP-2 vs GHRP-6

GHRP-2 and GHRP-6 are the two most-referenced members of the original GHRP series. They are compared constantly in the research literature because they share a mechanism but differ in secondary-axis profile.

Applicazioni di ricerca

GHRP-2 is used in studies examining:

• GH pulsatility and secretagogue-induced pulse amplitude
• IGF-1 downstream response to repeated GHRP administration
• Comparative ghrelin-mimetic research (GHRP-2 vs GHRP-6 vs ipamorelin)
• Paired GHRH + GHRP protocols (with CJC-1295 / sermorelin / tesamorelin)
• Ghrelin-receptor signaling and appetite-axis modulation
• Anti-doping analytics - GHRP-2 is a WADA-prohibited reference analyte

Specifiche tecniche

Storage & Handling

Unopened vials are kept at 2-8°C under standard cold-chain conditions and remain stable for 12+ months. Reconstitution parameters, solvent compatibility, and post-reconstitution stability for GHRP-2 are documented in the published peer-reviewed literature and standard peptide-chemistry references.

Reference Literature

Published clinical and preclinical GHRP-2 literature is available through PubMed, Google Scholar, and other peer-reviewed databases. WWP does not provide protocol design, dosing guidance, or administration parameters. Those decisions rest with the researcher and any applicable institutional review board.

Common Questions About GHRP-2 Research

What is GHRP-2 used for in research?

It is studied primarily as a ghrelin-receptor agonist for GH pulsatility and downstream IGF-1 endpoints. Comparative research against GHRP-6 and ipamorelin is common, as is paired research with GHRH analogs (CJC-1295, sermorelin, tesamorelin) where the GHRP provides the pulse and the GHRH extends it.

What is the difference between GHRP-2 and GHRP-6?

Both agonize the same GHSR-1a receptor. GHRP-2 produces a sharper, more selective GH pulse with a moderate appetite effect. GHRP-6 produces a broader GH pulse with a pronounced appetite-axis signal. Research protocols select between them based on whether the hunger-axis effect is a desired or unwanted variable.

Is GHRP-2 banned by WADA?

Yes. GHRP-2 (pralmorelin) appears on the WADA Prohibited List under S2 “Peptide Hormones, Growth Factors, Related Substances and Mimetics” and is prohibited at all times. It is frequently used as a reference analyte in anti-doping mass-spectrometry analytics.

Is GHRP-2 FDA approved?

No. GHRP-2 is not FDA approved for any use in the United States. It was developed as a diagnostic agent for GH deficiency testing in Japan but has not been submitted for US regulatory review. Every vial WWP ships is labeled and sold strictly for laboratory and research use only.

How is GHRP-2 stored?

Le fiale non aperte vanno conservate a una temperatura compresa tra 2 e 8 °C e mantengono la loro stabilità per oltre 12 mesi. Una volta ricostituita con acqua batteriostatica, la soluzione va conservata a una temperatura compresa tra 2 e 8 °C e utilizzata entro 28-30 giorni.

Garanzia di purezza

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