GHRP-2
Price range: $98.00 through $145.00
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GHRP-2 - Pralmorelin Ghrelin-Receptor Agonist Research Peptide
GHRP-2 (also known as pralmorelin, KP-102) is a synthetic hexapeptide first developed by Bowers and colleagues in the 1990s as a second-generation growth hormone-releasing peptide. It binds the GHSR-1a receptor (the ghrelin receptor) in the anterior pituitary and hypothalamus, triggering pulsatile growth hormone (GH) release without disturbing the native somatostatin feedback loop. GHRP-2 is the most-studied compound in the “ghrelin mimetic” research category and is used as the reference secretagogue alongside GHRP-6, ipamorelin, and hexarelin.
Why the GHSR-1a Binding Profile Matters
GHRP-2’s research distinction is its GH-release potency relative to its appetite-signaling effect. Most ghrelin-receptor agonists couple GH release with measurable increases in hunger-axis signaling (NPY, AgRP). GHRP-2 is positioned between GHRP-6 (strong appetite effect) and ipamorelin (minimal appetite effect) - its research utility is in protocols that want reliable GH pulsatility without the pronounced hunger-axis signal GHRP-6 produces.
| Pathway | What it does in plain terms |
|---|---|
| GHSR-1a (ghrelin receptor) | Agonized - triggers pulsatile GH release from anterior pituitary |
| IGF-1 | Downstream rise from repeated GH pulses |
| Appetite-axis (NPY/AgRP) | Moderate stimulation - less than GHRP-6, more than ipamorelin |
| Cortisol / prolactin | Mild elevation at higher doses reported in published work |
GHRP-2 vs GHRP-6
GHRP-2 and GHRP-6 are the two most-referenced members of the original GHRP series. They are compared constantly in the research literature because they share a mechanism but differ in secondary-axis profile.
| Compound | GH-release profile | Appetite effect |
|---|---|---|
| GHRP-2 | Strong, sharp pulse | Moderate |
| GHRP-6 | Strong, broader pulse | Pronounced |
| Ipamorelin | Cleaner, sel |
Minimal |
Research Applications
GHRP-2 is used in studies examining:
- GH pulsatility and secretagogue-induced pulse amplitude
- IGF-1 downstream response to repeated GHRP administration
- Comparative ghrelin-mimetic research (GHRP-2 vs GHRP-6 vs ipamorelin)
- Paired GHRH + GHRP protocols (with CJC-1295 / sermorelin / tesamorelin)
- Ghrelin-receptor signaling and appetite-axis modulation
- Anti-doping analytics - GHRP-2 is a WADA-prohibited reference analyte
Specifications
| Format | Lyophilized powder |
| Purity | ≥99% |
| Aliases | Pralmorelin, KP-102, growth hormone releasing peptide-2 |
| Available sizes | 5mg · 10mg |
| Storage | 2-8°C unopened; stable 12+ months |
| Use | Research purposes only - not for human use |
Storage & Handling
Unopened vials are kept at 2-8°C under standard cold-chain conditions and remain stable for 12+ months. Reconstitution parameters, solvent compatibility, and post-reconstitution stability for GHRP-2 are documented in the published peer-reviewed literature and standard peptide-chemistry references.
Reference Literature
Published clinical and preclinical GHRP-2 literature is available through PubMed, Google Scholar, and other peer-reviewed databases. WWP does not provide protocol design, dosing guidance, or administration parameters. Those decisions rest with the researcher and any applicable institutional review board.
Common Questions About GHRP-2 Research
What is GHRP-2 used for in research?
It is studied primarily as a ghrelin-receptor agonist for GH pulsatility and downstream IGF-1 endpoints. Comparative research against GHRP-6 and ipamorelin is common, as is paired research with GHRH analogs (CJC-1295, sermorelin, tesamorelin) where the GHRP provides the pulse and the GHRH extends it.
What is the difference between GHRP-2 and GHRP-6?
Both agonize the same GHSR-1a receptor. GHRP-2 produces a sharper, more sel
Is GHRP-2 banned by WADA?
Yes. GHRP-2 (pralmorelin) appears on the WADA Prohibited List under S2 “Peptide Hormones, Growth Factors, Related Substances and Mimetics” and is prohibited at all times. It is frequently used as a reference analyte in anti-doping mass-spectrometry analytics.
Is GHRP-2 FDA approved?
No. GHRP-2 is not FDA approved for any use in the United States. It was developed as a diagnostic agent for GH deficiency testing in Japan but has not been submitted for US regulatory review. Every vial WWP ships is labeled and sold strictly for laboratory and research use only.
How is GHRP-2 stored?
Unopened vials are stored at 2-8°C and stay stable for 12+ months. Once reconstituted with bacteriostatic water, the solution is kept at 2-8°C and used within 28-30 days.
Purity Guarantee
Every batch is ≥99% purity. Send us a COA from any independent test and we’ll issue store credit regardless of what it shows.
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