Selank

Selank - Tuftsin-Analog GABAergic Anxiolytic Research Peptide

Selank is a synthetic heptapeptide analog of the immune-regulatory peptide tuftsin, developed at the Russian Academy of Medical Sciences in the late 1990s as a nootropic / anxiolytic research compound alongside Semax. Structurally it is tuftsin (Thr-Lys-Pro-Arg) extended with a Pro-Gly-Pro C-terminal stabilizer, which gives Selank a plasma half-life long enough for CNS research that native tuftsin lacks. In research, Selank is the reference GABAergic-signaling research peptide - its anxiolytic endpoint profile overlaps with classical benzodiazepine research but through distinct mechanisms (enkephalin upregulation and modulation of GABAergic signaling rather than direct GABA-A binding).

Why the Tuftsin-Analog Structure Matters

Tuftsin (Thr-Lys-Pro-Arg) is a naturally occurring immune-system peptide that is rapidly cleaved in plasma. Selank’s C-terminal Pro-Gly-Pro extension is a stabilizer used across several Russian research peptides (Semax uses the same Pro-Gly-Pro tail). That extension gives Selank a circulating half-life of ~20+ minutes - long enough to cross the blood-brain barrier and reach CNS targets. Selank’s research distinction is that it engages the GABAergic / enkephalin axis rather than the melanocortin-derived ACTH fragments that anchor Semax.

Selank vs Semax

The two compounds are compared constantly in Russian nootropic-research literature. They share a Pro-Gly-Pro stabilizer tail but target completely different neurochemical axes.

Research Applications

Selank is used in studies examining:

• GABAergic and enkephalin-pathway anxiolytic endpoints
• Stress-response and anxiety models (generalized anxiety, neurasthenia)
• Serotonin turnover and mood-regulation research
• Comparative nootropic-peptide research (Selank vs Semax)
• Immune-modulation research (tuftsin-derived anti-viral endpoints)
• Non-benzodiazepine anxiolytic mechanism studies

Specifications

Storage & Handling

Unopened vials are kept at 2-8°C under standard cold-chain conditions and remain stable for 12+ months. Reconstitution parameters, solvent compatibility, and post-reconstitution stability for Selank are documented in the published peer-reviewed literature and standard peptide-chemistry references.

Reference Literature

Published clinical and preclinical Selank literature is available through PubMed, Google Scholar, and other peer-reviewed databases. WWP does not provide protocol design, dosing guidance, or administration parameters. Those decisions rest with the researcher and any applicable institutional review board.

Common Questions About Selank Research

What is Selank used for in research?

It is studied as the reference tuftsin-analog anxiolytic research peptide. Published work covers GABAergic / enkephalin-pathway anxiolytic endpoints, stress-response and anxiety models, serotonin turnover, immune-modulation research, and comparative nootropic-peptide research against Semax.

What is the difference between Selank and Semax?

Both are Russian-developed nootropic research peptides with the same Pro-Gly-Pro stabilizer tail, but they target different neurochemical systems. Selank is a tuftsin analog that engages the GABAergic / enkephalin anxiolytic axis. Semax is an ACTH(4-10) melanocortin fragment analog that engages the BDNF / dopaminergic cognitive-enhancement axis. Selank is anxiety-focused; Semax is cognition-focused.

What is N-Acetyl Selank Amidate?

N-Acetyl Selank Amidate is a modified variant of Selank with an acetyl group on the N-terminus and an amide cap on the C-terminus. Those modifications extend plasma half-life by increasing resistance to aminopeptidase and carboxypeptidase cleavage. In research, it shows up when longer duration of action is required than unmodified Selank provides.

Is Selank FDA approved?

No. Selank is not an FDA-approved drug product. It is approved as a prescription anxiolytic in Russia but has no regulatory status in the United States or European Union. Every vial WWP ships is labeled and sold strictly for laboratory and research use only.

How is Selank stored?

Unopened vials are stored at 2-8°C and stay stable for 12+ months. Once reconstituted with bacteriostatic water, the solution is kept at 2-8°C and used within 28-30 days.

Purity Guarantee

Every batch is ≥99% purity. Send us a COA from any independent test and we’ll issue store credit regardless of what it shows.