VIP

VIP — Vasoactive Intestinal Peptide Research Compound

VIP (Vasoactive Intestinal Peptide) is a 28-amino-acid neuropeptide first isolated from porcine intestine in 1970 by Said and Mutt. It is widely distributed through the central nervous system, gastrointestinal tract, immune cells, and vasculature – which is why it has been studied across neuroimmune, vasodilatory, and anti-inflammatory research axes. In the peptide-research toolkit, VIP is the reference neuropeptide for VPAC1/VPAC2 receptor characterization and for studies of Th1/Th2 cytokine balance.

Why VIP’s Multi-Receptor Profile Matters

VIP binds two G-protein-coupled receptors – VPAC1 and VPAC2 – that are expressed on different tissues. VPAC1 is concentrated on T cells, macrophages, and the intestinal epithelium; VPAC2 is concentrated on smooth muscle and the suprachiasmatic nucleus. That distribution is why a single peptide produces both immune-modulatory and vasodilatory signaling, and why VIP is cited across such a wide range of published research rather than sitting in one category.

Applicazioni di ricerca

VIP is used in studies examining:

• Anti-inflammatory signaling and Th1/Th2 cytokine balance
• VPAC1 and VPAC2 receptor characterization
• Vasodilation and smooth-muscle relaxation models
• Experimental arthritis and autoimmune-inflammation research
• Circadian signaling via suprachiasmatic nucleus endpoints
• CIRS (chronic inflammatory response syndrome) research literature

Specifiche tecniche

Ricostituzione

VIP arrives as a freeze-dried powder and is reconstituted with bacteriostatic water:

Totale in mg nella fiala ÷ ml di acqua aggiunta = mg per ml

Esempio: una fiala da 5 mg + 2 ml di acqua batteriostatica = 2,5 mg per ml. Una fiala da 10 mg + 2 ml = 5 mg per ml.

Una volta ricostituito, conservare a una temperatura compresa tra 2 e 8 °C e utilizzare entro 28-30 giorni.

Note sul protocollo

The following values are reference points extracted from published VIP research – not instructions. Because VIP has a short functional half-life (~2 minutes in circulation), the intranasal route is the most commonly documented research format in the published literature.

• Dose range reported in the literature: 50-200mcg per administration in published intranasal protocols
• Administration frequency in published studies: Typically 1-4x daily depending on endpoint
• Study durations reported: 4-12 weeks for inflammation and cytokine-balance endpoints

Common Questions About VIP Research

What is VIP peptide used for in research?

It is most commonly studied as a neuroimmune modulator. Published work covers anti-inflammatory signaling, Th1/Th2 cytokine balance, vasodilation, experimental arthritis models, and circadian signaling. It does not sit in a single category – VIP is cited across immune, vascular, and neuroscience literature.

What does VIP do in research models?

It binds two G-protein-coupled receptors (VPAC1 and VPAC2). VPAC1 activation modulates T-cell and macrophage cytokine release; VPAC2 activation produces smooth-muscle relaxation and vasodilation. The downstream effects cited in the literature include reduced pro-inflammatory cytokine output, vasodilation, and Th1/Th2 ratio shifts.

What is the difference between VIP and PACAP?

PACAP (pituitary adenylate cyclase-activating peptide) is VIP’s closest structural relative and shares the VPAC1 and VPAC2 receptors. PACAP also binds a third receptor (PAC1) with higher affinity than VIP. The two peptides are often studied together in neuroimmune research.

Is VIP FDA approved?

No. Vasoactive Intestinal Peptide is not FDA approved for any use. It is studied as a research compound only. Every vial WWP ships is labeled and sold strictly for laboratory and research use only.

How is VIP stored?

Le fiale non aperte vanno conservate a una temperatura compresa tra 2 e 8 °C e mantengono la loro stabilità per oltre 12 mesi. Una volta ricostituita con acqua batteriostatica, la soluzione va conservata a una temperatura compresa tra 2 e 8 °C e utilizzata entro 28-30 giorni.

Garanzia di purezza

Ogni lotto ha una purezza pari o superiore al 99%. Inviateci un certificato di analisi (COA) redatto da un ente indipendente e vi accrediteremo un buono acquisto indipendentemente dai risultati riportati.