Epithalon

Volume Pricing

Price per pack (10 vials). Discount applies to this compound only – no mix and match.

Epithalon — Pineal Tetrapeptide / Telomerase Activator & Geroprotective Agent

Epithalon (AEDG) is a synthetic tetrapeptide composed of four amino acids — Alanine, Glutamic acid, Aspartic acid, Glycine — synthesized as the bioactive analog of Epithalamin, a polypeptide complex originally isolated from bovine pineal gland tissue. First characterized and developed at the St. Petersburg Institute of Bioregulation and Gerontology under Professor Vladimir Khavinson beginning in the 1980s, Epithalon has since been confirmed to occur naturally within pineal gland polypeptide complex solution and has accumulated over 25 years of in vitro, in vivo, and in silico research data. Its molecular formula is C14H22N4O9.

Epithalon occupies a unique position in longevity and geroscience research by targeting what is widely regarded as one of the most fundamental biological clocks governing cellular aging: telomere length. In most human somatic cells, telomerase — the ribonucleoprotein enzyme responsible for adding protective telomeric repeats to chromosome ends — is silenced following development. As cells divide, telomeres progressively shorten until a critical threshold triggers senescence or apoptosis, a phenomenon known as the Hayflick limit. Epithalon’s primary documented mechanism is the reactivation of telomerase in previously telomerase-negative somatic cells, with demonstrated telomere elongation of approximately 33% in treated human fibroblasts — sufficient in cell culture models to surpass the Hayflick limit and extend replicative potential. Its research profile extends further into neuroendocrine regulation, antioxidant enzyme modulation, circadian rhythm support, and immune system maintenance, establishing it as a pleiotropic geroprotective compound.

Why Epithalon Matters in Longevity Research

Research Applications

Epithalon is used in studies examining:

• Telomere biology — telomerase activation, hTERT expression quantification, and telomere length measurement across cell types
• Cellular senescence and the Hayflick limit — replicative lifespan extension in somatic cell culture models
• Longevity and geroprotection — biomarkers of biological aging, mortality endpoints, and healthspan research in animal models
• Pineal gland and circadian biology — melatonin secretion dynamics, cortisol rhythm regulation, and sleep architecture in aged subjects
• Oncology models — spontaneous tumor incidence, metastasis suppression, and chromosomal stability under carcinogenic stress
• Oxidative stress and redox biology — antioxidant enzyme activity and free radical damage in aging tissue models
• Immune regulation — thymocyte proliferation, T-cell function, IL-2 signaling, and age-related immune decline
• Epigenetic reprogramming — gene expression modulation in stem cell and fibroblast models
• Retinal degeneration — parabulbar administration studies in retinitis pigmentosa models showing 90% positive response rate in one human clinical trial
• Chromosomal integrity — protection against future chromosomal aberrations in models of genomic instability

Specifications

Reconstitution

Epithalon arrives as lyophilized powder and must be reconstituted with sterile or bacteriostatic water prior to use. Use the formula:

Total mg ÷ Volume added (mL) = Concentration (mg/mL)

Example: 10mg vial + 2mL sterile water = 5mg/mL solution Example: 50mg vial + 5mL sterile water = 10mg/mL solution

Reconstituted solution should be stored at 2–8°C and used within 28–30 days.

Protocol Notes

Epithalon’s research protocols vary considerably by endpoint — cellular studies examining telomere dynamics use continuous low-dose exposure across multiple cell division cycles, while in vivo longevity and neuroendocrine studies employ discrete administration courses. Course-based rather than continuous administration is the predominant model in human and primate data, reflecting the peptide’s proposed mechanism of inducing durable downstream regulatory changes rather than requiring sustained saturation.

Typical research dosing framework:

• Dose range: 5–20mg per administration depending on model, route, and endpoint
• Frequency: Once daily in most studied protocols; some models use twice-daily administration
• Routes studied: Subcutaneous and intramuscular injection (primary research routes); intravenous in some clinical models; intranasal studied for CNS/pineal applications
• Study duration: 10–20 day discrete courses most common in human and primate data; repeated annual courses studied in longevity cohort protocols
• Combination protocols: Studied alongside thymalin (thymic peptide extract) in mortality endpoint research, with synergistic effects observed

Commonly observed effects in research models:

• Circadian/sleep-related: Improved melatonin secretion patterns and circadian rhythm normalization in aged subjects; sleep architecture improvements noted in observational data
• Systemic: Generally well-tolerated across human and animal study populations; no significant organ toxicity signals in available literature
• Tolerability context: Epithalon’s tetrapeptide simplicity and endogenous origin make it among the better-characterized short peptides from a safety standpoint; long-term safety data in human populations remains limited to the available cohort studies

Research Stacks

Epithalon is commonly paired in research settings with:

• Thymosin Alpha-1 — Thymosin Alpha-1 modulates T-cell differentiation and innate immune signaling; it is paired with Epithalon in longevity and immune-aging models where pineal-immune crosstalk and telomere biology are studied concurrently.
• MOTS-c — MOTS-c activates AMPK and regulates nuclear gene expression from a mitochondrial-encoded origin; it is studied alongside Epithalon in aging models examining mitochondrial and epigenetic dimensions of cellular senescence.
• SS-31 — SS-31 reduces mitochondrial oxidative stress by targeting cardiolipin at the inner membrane; pairing it with Epithalon allows researchers to examine telomerase-activating and mitochondrial-protective interventions in the same aging model.

Purity Guarantee

Every batch is ≥99% purity. If you independently test your compound and the results don’t match our certificate of analysis — send us the COA and we’ll issue store credit, no questions asked.