$325.00
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Price per pack (10 vials). Discount applies to this compound only – no mix and match.
| 5mg | ||
|---|---|---|
| Quantity | Price per Pack | Savings |
| 1 pack | $325 per pack | |
| 2 packs | $276 per pack | 15% off |
| 3 packs | $235 per pack | 28% off |
| 5 packs | $211 per pack | 35% off |
| 10 packs | $190 per pack | 42% off |
| 25 packs | $171 per pack | 47% off |
Sermorelin is a synthetic 29-amino acid peptide corresponding to the N-terminal fragment of endogenous growth hormone-releasing hormone (GHRH), designated GHRH(1-29)NH₂. The compound was characterized during the 1970s and 1980s as researchers mapped the minimal active sequence of hypothalamic GHRH required for full biological activity at pituitary somatotrophs. It was subsequently approved by the FDA as Geref (sermorelin acetate) for diagnostic assessment of growth hormone secretory capacity and for treatment of idiopathic growth hormone deficiency in children — an approval that remained active until voluntary market withdrawal in 2008 for commercial rather than safety reasons. Sermorelin’s mechanism is fundamentally different from exogenous GH administration: it acts upstream at the pituitary, preserving the physiological pulsatile release pattern that characterizes normal somatotroph function. The 29-residue sequence retains full receptor activity compared to native 44-residue GHRH, and its relatively short plasma half-life (approximately 10–12 minutes) makes it a tractable tool compound for GH axis characterization in research settings.
Sermorelin acts on the GHRH receptor (GHRHR), a Gs-coupled GPCR expressed specifically on anterior pituitary somatotroph cells. GHRHR activation elevates intracellular cAMP via adenylyl cyclase, which drives both acute GH release and longer-term GH gene transcription. Because sermorelin stimulates endogenous GH secretion rather than bypassing it, the physiological feedback loop via somatostatin remains intact — a critical distinction for research models examining the full hypothalamic-pituitary-somatotroph axis. This preserved feedback architecture means IGF-1 elevation follows normal somatotroph kinetics rather than the supraphysiological curves produced by direct GH injection.
| Mechanism | Effect |
|---|---|
| GHRHR agonism on somatotrophs | cAMP elevation → protein kinase A activation → GH synthesis and acute secretion |
| Pulsatile GH release preservation | Somatostatin feedback remains active; physiological GH pulse amplitude and frequency maintained |
| Downstream IGF-1 upregulation | GH-dependent hepatic IGF-1 synthesis; soft tissue and bone anabolic signaling in research models |
| GH gene transcription (chronic exposure) | Somatotroph hypertrophy and GH mRNA upregulation in extended rodent studies |
Sermorelin is used in studies examining:
| Format | Lyophilized powder |
| Purity | ≥99% |
| Aliases | GHRH(1-29), GRF(1-29)NH₂, sermorelin acetate, Geref |
| Available sizes | 5mg |
| Storage | 2–8°C unopened; stable 12+ months |
| Use | Research purposes only — not for human use |
Sermorelin arrives as lyophilized powder and must be reconstituted with bacteriostatic water prior to use. Use the formula:
Total mg ÷ Volume added (mL) = Concentration (mg/mL)
Example: 5mg vial + 1mL BAC water = 5mg/mL solution
Reconstituted peptide should be stored at 2–8°C and used within 28–30 days.
Research frameworks for sermorelin are grounded in its former FDA-approved clinical use and published pediatric/adult GH deficiency literature. Diagnostic protocols used single-dose IV bolus administration; therapeutic research used lower-dose subcutaneous administration at bedtime to align with physiological nocturnal GH secretion patterns.
Sermorelin is commonly paired in research settings with:
Every batch is ≥99% purity. If you independently test your compound and the results don’t match — send us the COA and we’ll issue store credit, no questions asked.
