HCG

hCG — Human Chorionic Gonadotropin Research Compound

Human chorionic gonadotropin (hCG) is a glycoprotein hormone naturally produced by the placenta during pregnancy, structurally related to luteinizing hormone (LH) and sharing a nearly identical alpha subunit. In research, hCG is the reference LH-receptor agonist – it binds the same LH receptor on Leydig cells (testes) and theca cells (ovaries) that pituitary LH does, triggering direct gonadal steroidogenesis. Because hCG acts at the bottom of the hypothalamic-pituitary-gonadal (HPG) axis rather than at the top, it is a foundational tool in reproductive-endocrinology research.

Why the LH-Receptor Binding Profile Matters

hCG’s structural overlap with LH is what gives it research utility. It binds the LH/hCG receptor with a longer plasma half-life than endogenous LH pulses (roughly 24-36 hours vs minutes), producing a sustained downstream steroidogenic signal. That pharmacokinetic difference is the reason hCG is studied instead of native LH in protocols that require Leydig or theca cell stimulation across a longer time window.

hCG vs Kisspeptin-10 vs GnRH Analogs

All three raise downstream testosterone or estradiol in published work, but they act at different levels of the HPG axis.

Applicazioni di ricerca

hCG is used in studies examining:

• Leydig-cell steroidogenesis and testosterone output endpoints
• Theca-cell androgen precursor synthesis
• Testicular volume and function under suppressed endogenous LH
• Ovulation-induction research (ovarian follicle maturation endpoints)
• Cryptorchidism and delayed-puberty endocrine models
• Comparative HPG-axis research vs GnRH analogs and kisspeptin

Specifiche tecniche

Ricostituzione

hCG arrives as a freeze-dried powder and is reconstituted with bacteriostatic water:

Total IU in the vial ÷ mL of water added = IU per mL

Example: a 5,000 IU vial + 5mL of bacteriostatic water = 1,000 IU per mL. A 10,000 IU vial + 10mL = 1,000 IU per mL.

Una volta ricostituito, conservare a una temperatura compresa tra 2 e 8 °C e utilizzare entro 28-30 giorni.

Note sul protocollo

The following values are reference points extracted from published hCG research – not instructions. Because hCG has a long plasma half-life relative to native LH pulses, published protocols typically use intermittent dosing rather than daily administration.

• Dose range reported in the literature: 250-3,000 IU per administration (varies widely by endpoint)
• Frequenza di somministrazione negli studi pubblicati: da due a tre volte alla settimana
• Study durations reported: 6-26 weeks for gonadal-function endpoints

Common Questions About hCG Research

What is hCG used for in research?

It is studied as the reference LH-receptor agonist. Published work covers Leydig-cell testosterone output, theca-cell androgen synthesis, testicular volume maintenance under suppressed endogenous LH, ovulation-induction endpoints, and cryptorchidism / delayed-puberty endocrine models.

What is the difference between hCG and LH?

Both bind the LH/hCG receptor and trigger the same downstream steroidogenic cascade. hCG has a much longer plasma half-life (24-36 hours vs minutes for native LH pulses), which is why it shows up in research protocols that require sustained receptor activation rather than pulsatile signaling.

How does hCG compare to GnRH analogs or kisspeptin?

hCG acts at the bottom of the HPG axis (gonadal receptor). GnRH analogs act at the pituitary. Kisspeptin acts above GnRH in the hypothalamus. The three compounds are used to isolate different levels of axis function – hCG bypasses the hypothalamus and pituitary entirely, which makes it the cleanest tool for studying gonadal response in isolation.

Is hCG FDA approved?

hCG has been FDA approved as Pregnyl and Novarel for specific reproductive indications (cryptorchidism, infertility). Research-grade hCG is not sold under those brand labels and is distinct from the approved drug products. Every vial WWP ships is labeled and sold strictly for laboratory and research use only.

How is hCG stored?

Le fiale non aperte vanno conservate a una temperatura compresa tra 2 e 8 °C e mantengono la loro stabilità per oltre 12 mesi. Una volta ricostituita con acqua batteriostatica, la soluzione va conservata a una temperatura compresa tra 2 e 8 °C e utilizzata entro 28-30 giorni.

Garanzia di purezza

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