HMG

hMG - Human Menopausal Gonadotropin (FSH + LH) Research Compound

Human menopausal gonadotropin (hMG) is a gonadotropin preparation that contains both follicle-stimulating hormone (FSH) and luteinizing hormone (LH) activity, historically purified from the urine of postmenopausal donors. Each 75 IU ampule contains approximately 75 IU of FSH activity and 75 IU of LH activity in a 1:1 ratio. In reproductive-endocrinology research, hMG is the reference “combined gonadotropin” preparation - it supplies both receptor inputs to the gonad rather than isolating one, which is why it sits at a different point in the research toolkit than pure FSH or pure hCG preparations.

Why the Dual FSH + LH Profile Matters

The ovary and testis use FSH and LH together. FSH drives granulosa / Sertoli cell function; LH drives theca / Leydig cell steroidogenesis. Studying either axis in isolation misses the cross-talk between the two compartments. hMG’s research utility is that it supplies both signals simultaneously at a fixed ratio, which is the mechanism pituitary output produces in vivo. That is why it is the reference preparation in published ovulation-induction and controlled ovarian hyperstimulation research.

hMG vs hCG vs Pure FSH

The three gonadotropin preparations are compared constantly in reproductive research because each isolates a different combination of the two gonadotropin signals.

Research Applications

hMG is used in studies examining:

• Controlled ovarian hyperstimulation and follicle-maturation endpoints
• Spermatogenesis and Sertoli-cell function models
• Combined gonadotropin signaling and receptor cross-talk
• Comparative gonadotropin research (hMG vs recombinant FSH vs hCG)
• Hypogonadotropic hypogonadism restoration-of-function models
• Assisted-reproductive-technology (ART) endocrine pharmacology

Specifications

Storage & Handling

Unopened vials are kept at 2-8°C under standard cold-chain conditions and remain stable for 12+ months. Reconstitution parameters, solvent compatibility, and post-reconstitution stability for HMG are documented in the published peer-reviewed literature and standard peptide-chemistry references.

Reference Literature

Published clinical and preclinical HMG literature is available through PubMed, Google Scholar, and other peer-reviewed databases. WWP does not provide protocol design, dosing guidance, or administration parameters. Those decisions rest with the researcher and any applicable institutional review board.

Common Questions About hMG Research

What is hMG used for in research?

It is studied as the combined FSH + LH gonadotropin preparation. Published work covers controlled ovarian hyperstimulation and follicle maturation, spermatogenesis and Sertoli-cell function under restored gonadotropin signaling, and comparative research against pure FSH and hCG preparations.

What is the difference between hMG and hCG?

hCG is an LH-receptor agonist only. hMG supplies both FSH and LH activity at a 1:1 ratio. Research protocols use hCG when only the gonadal steroidogenic signal is needed; hMG is used when the goal is to supply both gonadotropin inputs to match natural pituitary output more closely.

What is the difference between hMG and recombinant FSH?

Recombinant FSH contains only FSH activity. hMG contains both FSH and LH activity. Comparative research between the two preparations is a major topic in reproductive endocrinology because LH content matters for theca-cell steroidogenesis and follicle quality endpoints.

Is hMG FDA approved?

hMG is FDA approved under brand names like Menopur and Repronex for specific reproductive indications. Research-grade hMG is not sold under those brand labels and is distinct from the approved drug products. Every vial WWP ships is labeled and sold strictly for laboratory and research use only.

How is hMG stored?

Unopened vials are stored at 2-8°C and stay stable for 12+ months. Once reconstituted with bacteriostatic water, the solution is kept at 2-8°C and used within 28-30 days.

Purity Guarantee

Every batch is ≥99% purity. Send us a COA from any independent test and we’ll issue store credit regardless of what it shows.